Research advances in hepatocellular carcinoma-related imbalance of bile acid metabolism and related regulatory mechanism
DOI:10.3969/j.issn.1001-5256.2021.03.038
- VernacularTitle:肝细胞癌相关胆汁酸代谢失衡及调控机制的研究进展
- Author:
Zherui LIU
1
;
Xiaodong JIA
;
Yinying LU
Author Information
1. Peking University 302 Clinical Medical School, Beijing 100039, China
- Publication Type:Research Article
- Keywords:
Carcinoma, Hepatocellular;
Bile Acids and Salts;
Gastrointestinal Microbiome
- From:
Journal of Clinical Hepatology
2021;37(3):690-694
- CountryChina
- Language:Chinese
-
Abstract:
Bile acid metabolism, gut microbiota, and bile acid receptors are involved in the development and progression of hepatocellular carcinoma (HCC). There are substantial increases in the levels of some bile acids, such as glycocholic acid, taurocholic acid, and taurochenodeoxycholic acid, in the liver tissue of HCC mice and the serum and feces of HCC patients. Bile acid metabolism due to the imbalance of the abundance of bacteria producing bile salt hydrolases and Clostridium in the intestine and the change in immune microenvironment may also promote the development of HCC. Moreover, some bile acid receptors, such as farnesoid X receptor, G protein-coupled bile acid receptor 1, pregnane X receptor, constitutive androstane receptor, and sphingosine-1-phosphate receptor 2, have been shown to participate in the development and progression of HCC through various pathways. Each link of bile acid metabolism plays a different role in the progression of HCC, and a systematic elaboration of the interaction between these links may help to deepen the understanding of the pathogenesis of HCC and develop the biological targets for early diagnosis, prognosis prediction, and precise treatment.
