Research advances in direct infection of renal tubular cells by hepatitis B virus
DOI:10.3969/j.issn.1001-5256.2021.03.036
- VernacularTitle:HBV感染肾小管细胞机制的研究进展
- Author:
Yingjuan LI
1
;
Guohe FENG
Author Information
1. Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang 110000, China
- Publication Type:Research Article
- Keywords:
Hepatitis B Virus;
Kidney Tubules;
Infection
- From:
Journal of Clinical Hepatology
2021;37(3):681-684
- CountryChina
- Language:Chinese
-
Abstract:
The kidney plays a key role in hepatitis B virus (HBV) infection of liver cells. The pathogenesis of HBV-associated glomerulonephritis (HBV-GN) remains unclear, and the mechanism of HBV directly causing the injury of renal tubules has been taken seriously in recent years. HBV can induce the apoptosis of renal tubular cells by regulating cell cycle and activating related signaling pathways including NF-κB and thus lead to the progression of HBV-GN. At present, there are still no drugs targeting the kidney in the treatment of HBV-GN. This article summarizes the research advances in the key factors for HBV infection of cells and the injury of renal tubular cells caused by HBV and elaborates on the possible mechanism of direct infection of renal tubular cells by HBV, so as to provide new ideas for the treatment of HBV-GN.
