Role of gut microbiota in the treatment of ulcerative colitis with traditional Chinese medicine
10.16438/j.0513-4870.2020-1802
- VernacularTitle:肠道菌群在中草药抗溃疡性结肠炎中的作用
- Author:
Zhu-ping TAO
1
;
Yu LONG
2
;
Can-wei LI
3
;
Ai-wu YIN
4
;
Meng-ran FAN
1
;
Ying LI
1
;
Wei-hong LIU
5
;
Peng-fei GAO
1
,
6
,
7
Author Information
1. College of Pharmacy, Dali University, Dali 671000, China
2. The Second Hospital of Nanhua University, Hengyang 421001, China
3. College of Public Health, Dali University, Dali 671000, China
4. Xiangtan Medicine and Health Vocational College, Xiangtan 411104, China
5. College of Agriculture and Biological Science, Dali University, Dali 671000, China
6. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&
7. D, Dali 671000, China
- Publication Type:Research Article
- Keywords:
ulcerative colitis;
gut microbiota;
mechanism;
traditional Chinese medicine
- From:
Acta Pharmaceutica Sinica
2021;56(2):391-402
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease, listed as a modern refractory disease by the World Health Organization, which is difficult to recover, whereas it is easy to be attacked repeatedly. UC pathogenesis is closely related to gut microbiota dysbiosis. The gut microbiota interacts with bile acids (BAs), short-chain fatty acids (SCFAs), tryptophan, and other metabolism, immune system, intestinal barrier, etc., which regulate each other and affect the occurrence and development of UC. The active ingredients of traditional Chinese medicine (TCM), single herb and its extracts, and formulae can effectively alleviate UC symptoms by regulating the diversity, structure, composition, and metabolites of gut microbiota. In this review, the TCM based on the regulation of gut microbiota in the treatment of UC and its related mechanism for nearly three years was summarized.
