Research advances in the effect and utilization of protein corona on the circulation of nanoparticles in vivo
10.16438/j.0513-4870.2020-1323
- VernacularTitle:蛋白冠对纳米粒体内循环的影响和应用研究进展
- Author:
Dong-yan ZHOU
;
Cheng JIANG
;
Zhi-yu GUAN
;
Wei-feng ZHU
;
Ling-yun ZHONG
;
Jing LIU
;
Rong-hua LIU
- Publication Type:Research Article
- Keywords:
protein corona;
nanoparticle;
phagocytosis;
long circulation;
physical and chemical property;
surface modification
- From:
Acta Pharmaceutica Sinica
2021;56(2):487-495
- CountryChina
- Language:Chinese
-
Abstract:
Nanoparticles have better applicability in the detection, treatment of cancer and various difficult diseases, but mononuclear phagocytosis system can seriously shorten the time of nanoparticles in vivo circulation, reduce the drug efficacy. The protein crown formed on the surface of the nanoparticle after entering the body can change its surface properties, interfere with the recognition of phagocytes, and thus affect its circulation time in vivo. This article outlines the general composition and formation process of protein crowns. It also summarizes the influence of the physical and chemical properties of nanoparticles, such as particle size, surface charge, hydrophilicity and surface materials on the formation of protein crowns. The protein crown affects the circulation of nanoparticles in vivo, mainly because the adsorbed opsonic protein promotes cell phagocytosis. Therefore, we also introduce the method of using protein crowns to promote the long circulation of nanoparticles in vivo. By designing appropriate physical and chemical properties, surface modification, and directed design of protein crowns, the adsorption of proteins on the surface of nanoparticles can be reduced. Therefore, it can reduce the clearance of nanoparticles in the mononuclear phagocytic system (mainly the phagocytes of the liver and spleen), and achieve the goal of long circulation of nanoparticles in the body.
