Research advances on the protective effects and mechanism of salvianolic acids against ischemic heart disease
10.16438/j.0513-4870.2020-1277
- VernacularTitle:丹酚酸对缺血性心脏病的作用及作用机制研究进展
- Author:
Awaguli DAWUTI
;
Lian-hua FANG
;
Guan-hua DU
- Publication Type:Research Article
- Keywords:
italic>Salvia miltiorrhiza;
ater-soluble component;
salvianolic acid A;
salvianolic acid B;
ischemic heart disease
- From:
Acta Pharmaceutica Sinica
2021;56(2):368-373
- CountryChina
- Language:Chinese
-
Abstract:
Salvianolic acids are the main water-soluble active compounds of Salvia miltiorrhiza and have been widely used for the treatment of cardiovascular diseases. Based on the latest studies in China and abroad, we summarize the pharmacological effects and mechanism of salvianolic acids on ischemic heart disease by describing how salvianolic acid A and salvianolic acid B protect the vascular endothelium, relax coronary arteries, promote angiogenesis and anti-platelet aggregation, inhibit the inflammatory response, anti-cell apoptosis, and scavenge free radicals. This review provides a theoretical basis for further research on the effects of salvianolic acids on ischemic heart disease and their potential for drug development.
