Progress of researches on animal models of Blastocystis hominis infections

VernacularTitle:人芽囊原虫感染动物模型构建研究进展
Author: Xia FENG ¹ ; Fu-Qiang ZHANG ¹ ; Fu-Yang XU ¹ ; Xue-Fang MEI ^{1
,

2} ; Zhen-Chao ZHANG ^{1
,

2} ; Xiang-Rui LI ^{1
,

2
,

3} ; Shuai WANG ^{1
,

2}
Author Information

1. School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China
2. Xinxiang Key Laboratory of Pathogenic Biology, Xinxiang Medical University, China
3. College of Veterinary Medicine, Nanjing Agricultural University, China
Publication Type:Journal Article
Keywords: Blastocystis hominis; Animal model; Route of infection; Dose of infection; Influencing factor
From: Chinese Journal of Schistosomiasis Control 2021;33(1):102-106
CountryChina
Language:Chinese
Abstract: Blastocystis hominis is a common parasitic protozoa in human and animal intestines; however, its pathogenicity remains controversial. Construction of animal models is of great significance to investigate the pathogenicity, pathogenic mechanisms and drug screening of B. hominis. Experimental animals, mode of infections, parasite strains and host immune status are important factors affecting the successful modeling of B. hominis infections in animals. Hereby, we review the progress of researches on animal models of B. hominis infections, and summarize the influencing factors and application of animal models of B. hominis infections, in order to provides insights into the selection of animals models of B. hominis infections.