Effect of the regulation of mitochondrial dynamics on renal ischemia-reperfusion injury
10.3969/j.issn.1674-7445.2021.02.015
- VernacularTitle:线粒体动力学调控对肾缺血-再灌注损伤的影响
- Author:
Xiaodong YAN
1
;
Qiang WANG
Author Information
1. Hebei North University, Zhangjiakou 075000, China
- Publication Type:Research Article
- Keywords:
Ischemia-reperfusion injury (IRI);
Renal transplantation;
Mitochondrial division;
Mitochondrial fusion;
Fission (Fis) 1;
Mitofusin (Mfn);
Dynamin-related protein (Drp) 1;
Optic atrophy (OPA)1
- From:
Organ Transplantation
2021;12(2):226-
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion injury (IRI) is one of the main causes of early graft dysfunction after renal transplantation. In China, organ transplantation has entered into the era of organ donation after citizen's death. The increased risk of cardiopulmonary resuscitation, prolonged hypoperfusion time and warm ischemia time of donors may lead to IRI of the graft, and affect the short- and long-term clinical prognosis of the recipient and graft. Under IRI and other stress conditions, the mechanism of mitochondrial dynamics, mainly manifested by dynamic regulation of mitochondrial division and fusion, exert critical effect upon the biological function of mitochondria. Cell apoptosis caused by mitochondrial injury is the key event leading to acute kidney injury, which is mainly manifested by the imbalance of the regulatory mechanism of mitochondrial dynamics. In this article, the research progress on the regulatory mechanism of mitochondrial dynamics on renal IRI was reviewed, aiming to provide reference for improving the clinical outcomes of renal transplantation.
