Role of NLRP3 inflammasome and related inflammatory signaling pathways in renal ischemia-reperfusion injury
10.3969/j.issn.1674-7445.2021.02.007
- VernacularTitle:NLRP3炎症小体与相关炎症信号通路在肾缺血-再灌注损伤中的作用
- Author:
Qiang YUAN
1
;
Kaiwen SHEN
;
Ruibo ZHANG
;
Jun SHEN
Author Information
1. Guizhou Medical University, Guiyang 550004, China
- Publication Type:Research Article
- Keywords:
Ischemia-reperfusion injury (IRI);
Renal transplantation;
NOD-like receptor protein 3 (NLRP3);
Toll-like receptor (TLR);
Pattern recognition receptor (PRR);
Cysteinyl aspartate specific proteinase (Caspase)-1;
Mitochondrial DNA (mtDNA)
- From:
Organ Transplantation
2021;12(2):177-
- CountryChina
- Language:Chinese
-
Abstract:
Renal ischemia-reperfusion injury (IRI) commonly occurs in renal transplantation, which is an important pathophysiological process that causes acute renal failure and severely affects clinical prognosis of the recipients. Inflammatory response plays a critical role in the pathogenesis and pathological process of IRI. Activated NOD-like receptor protein 3(NLRP3) inflammasome can mediate the maturation and release of various pro-inflammatory cytokines, thereby regulating the inflammatory response and relevant cell functions. In this article, the mechanism underlying NLRP3 inflammasome and its related inflammatory signaling pathway in renal IRI were reviewed, aiming to provide novel ideas for clinical prevention and treatment of renal IRI.
