Experimental research progress on immunology of organ transplantation in 2020
10.3969/j.issn.1674-7445.2021.02.004
- VernacularTitle:2020年器官移植免疫学实验研究进展
- Author:
Qianchuan TIAN
1
;
Changhong WU
;
Yanan XU
;
Yong ZHAO
Author Information
1. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
- Publication Type:Research Article
- Keywords:
Organ transplantation;
Experimental research;
Immune tolerance;
Rejection;
Cytotoxic T lymphocyte-associated antigen;
Toll-like receptor;
Myeloid-derived suppressor cell;
Programmed cell death protein-ligand 1
- From:
Organ Transplantation
2021;12(2):143-
- CountryChina
- Language:Chinese
-
Abstract:
Despite the rapid development of organ transplantation technique, the long-term survival and functional maintenance of transplant organs still depend on the massive use of immunosuppressants.At present, the rejection and infection after organ transplantation remain the major problem facing transplant surgeons and recipients. The basic research in the field of organ transplantation is still steadily advancing to further explore the basic biological principle of rejection and immune tolerance, resolve multiple pathophysiological questions in the process of clinical organ transplantation and provide basic theoretical basis and clinical intervention guidance for wider and more effective application of organ transplantation.In 2020, researchers have achieved significant progresses on a wide range of basic researches of organ transplantation, such as the fundamental principle of immune response, overcoming transplantation rejection and inducing transplantation immune tolerance, etc.In this article, novel attempts and progresses upon inducing transplantation immune tolerance in 2020 were reviewed from two perspectives including inhibition of immune cell function and suppression of immune signaling pathway, and the main development direction of immunology of organ transplantation in the future was prospected.
