Pathology of T cell-mediated rejection in renal allograft
10.3969/j.issn.1674-7445.2021.02.003
- VernacularTitle:移植肾T细胞介导的排斥反应的病理学
- Author:
Hui GUO
1
Author Information
1. Organ Transplantation Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation of Ministry of Education, Key Laboratory of Organ Transplantation of National Health Commission of China, Key Laboratory of Organ Transplantation of Chinese Academy of Medical Sciences, Wuhan 430030, China
- Publication Type:Research Article
- Keywords:
Banff classification on allograft pathology (Banff classification);
T cell-mediated rejection (TCMR);
Antibody-mediated rejection (AMR);
Chronic allograft vasculopathy (CAV);
Chronic allograft damage index (CADI);
Tubular atrophy;
Interstitial fibrosis;
Endoarteritis
- From:
Organ Transplantation
2021;12(2):134-
- CountryChina
- Language:Chinese
-
Abstract:
T cell-mediated rejection (TCMR) is one of the main mechanisms of rejection in organ transplantation, which is also the most common type of acute rejection.Based on Banff classification on allograft pathology (Banff classification) in 2019, TCMR can be divided into acute TCMR (aTCMR) and chronic active TCMR (caTCMR) according to the characteristics of immune lesions.In this article, the basic definition of TCMR, the research progress on TCMR pathology according to Banff classification for renal allograft, and the basic pathological changes and diagnostic grading of TCMR were reviewed, aiming to provide evidence for early identification, diagnosis and treatment of TCMR and prevent the progression of TCMR into caTCMR, thereby guarantying the long-term survival of both the renal allograft and recipient.
