Research progress on the Hippo-YAP signaling pathway mediated osteoimmunology in modulating implant osseointegration
10.12016/j.issn.2096-1456.2021.05.007
- Author:
ZHOU Anqi
1
,
2
;
LIU Jiayi
1
,
2
;
JIA Yinan
1
,
2
;
XIANG Lin
1
,
3
Author Information
1. State Key Laboratory of Oral Diseases &
2. National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
3. National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University
- Publication Type:Review
- Keywords:
osseointegration;
bone repair;
Hippo-YAP signaling pathway;
osteoimmunology;
implants;
osteogenesis;
bone remodeling;
macrophages
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(5):334-339
- CountryChina
- Language:Chinese
-
Abstract:
Ideal osseointegration is intimately related to favorable osteoimmune properties around dental implants. An increasing number of in vitro and in vivo studies have indicated that the Hippo-YAP signaling pathway is involved in this biological process. In this article, the implicated roles of Hippo-YAP the signaling axis in peri-implant osteoimmunology were summarized by reviewing relevant evolving literature. The discrepancy concerning the Hippo-YAP signaling regulatory effect on osteogenesis and polarization direction were analyzed as well as propose the potential mechanism, which may be caused by the maturation of osteogenesis-related cells and heterogeneity of macrophages. More attention should be given to the requirements of promoting osteogenesis and patterns of regulating the immune microenvironment by Hippo-YAP in future studies.
- Full text:Hippo-YAP信号轴介导骨免疫调节种植体骨结合的研究进展.pdf
