Effects of smoking and drinking status before operation on recurrence and metastasis of esophageal squamous cell carcinoma
- VernacularTitle:术前吸烟及饮酒状态对食管鳞状细胞癌术后复发和转移的影响
- Author:
Jianfei ZHU
1
,
2
,
3
;
Yawei DOU
1
,
2
,
3
;
Wei TIAN
1
,
2
,
3
;
Yun DAI
1
,
2
,
3
;
Xianghui LUO
1
,
2
,
3
;
Yaohua CHEN
1
,
2
,
3
;
Hongtao WANG
1
,
2
,
3
;
Zhe LI
4
,
5
,
6
,
7
Author Information
1. Department of Thoracic Surgery, Shannxi Provincial People'
2. s Hospital, Xi'
3. an, 710068, P.R.China
4. Department of Hematology and Oncology, Yan&rsquo
5. an People&rsquo
6. s Hospital, Yan&rsquo
7. an, 716000, Shanxi, P.R.China
- Publication Type:Journal Article
- Keywords:
Smoking status;
drinking status;
esophageal squamous cell cancer;
prognosis;
surgery
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2021;28(02):219-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of smoking and drinking status on the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Methods The clinical data of 483 patients with ESCC who underwent surgical treatment in Shannxi Provincial People's Hospital from 2007 to 2016 were retrospectively analyzed. Among them, 352 patients were male and 131 were female, with a median age of 64 (37-80) years. There were 311 smokers and 172 drinkers. The relationship between preoperative drinking or smoking status and the clinicopathological characteristics of patients with ESCC was analyzed. Log-rank method and Cox risk regression were used to conduct univariate and multivariate survival analysis, respectively. Results The preoperative smoking status was related to the patient's tumor location (P=0.030). Drinking status was associated with tumor location (P=0.001), degree of differentiation (P=0.030), pathological T stage (P=0.024) and pathological N stage (P=0.029). Univariate survival analysis showed that smoking status did not affect the disease-free survival (DFS) (P=0.188) and overall survival (OS) (P=0.127) of patients with ESCC. However, patients who drank alcohol had worse PFS than non-drinking patients (29.37 months vs. 42.87 months, P=0.009). It was further proved that alcohol consumption was an independent risk factor affecting patients' recurrence and metastasis by using multivariate analysis (RR=1.28, P=0.040). Alcohol consumption also reduced the OS of patients by 21.47 months (P=0.014), however, multivariate analysis did not yield significant results. Conclusion Preoperative drinking status is related to the stage and differentiation of patients with ESCC. It is an independent risk factor affecting the recurrence and metastasis of ESCC.
