Preparation and properties of injectable minocycline hydrochloride microsphere depot
10.11665/j.issn.1000-5048.20210107
- VernacularTitle:注射用盐酸米诺环素微球贮库的制备及其性能研究
- Author:
Ting ZHANG
1
;
Hang LIAO
;
Yuting CHENG
;
Xiaohong WU
Author Information
1. 重庆医科大学附属口腔医院
- Publication Type:Journal Article
- Keywords:
minocycline hydrochloride;
poly(lactic-co-glycolic acid);
sucrose acetate isobutyrate;
electrospray
- From:
Journal of China Pharmaceutical University
2021;52(1):52-59
- CountryChina
- Language:Chinese
-
Abstract:
To prepare a minocycline hydrochloride microsphere depot and evaluate its release performance and physicochemical properties, poly (lactic-co-glycolic acid) (PLGA) was used as raw material, the minocycline hydrochloride microspheres were prepared by electrospray, and the morphology and size distribution of the microspheres were characterized by polarizing microscopy and scanning electron microscopy (SEM). The microspheres were then mixed with sucrose acetate isobutyrate (SAIB) depot at a ratio of 1:10 to form a minocycline hydrochloride microsphere depot, and its release performance and porosity changes were evaluated. The results showed that the microspheres had smooth surface and the diameter was (5.294 ± 1.222) μm. After the microspheres were added into SAIB depot, the burst release of minocycline hydrochloride significantly decreased from 60% to 3.27% at the first day, and then the release lasted for 42 days . Additionally, the porosity of the depot increased rapidly from (12.53 ± 0.43)% to (32.53 ± 0.43)% during days 0-15, and increased slowly from (32.53 ± 0.43)% to (33.81 ± 0.54)% during days 15-45. The minocycline hydrochloride microsphere depot prepared in this study is expected to be an effective way for the application of minocycline hydrochloride for its good release performance and simple preparation process.
