Self-assembling dendrimers for biomedical applications
10.11665/j.issn.1000-5048.20210103
- VernacularTitle:自组装型树形分子在生物医学领域的研究进展
- Author:
Kangjie SHI
1
;
Jiaxuan CHEN
;
Xiaoxuan LIU
;
Ling PENG
Author Information
1. 中国药科大学,天然药物活性组分与药效国家重点实验室
- Publication Type:Journal Article
- Keywords:
poly(amidoamine) dendrimer;
self-assembling dendrimers;
dendrimer synthesis;
drug delivery;
gene delivery
- From:
Journal of China Pharmaceutical University
2021;52(1):20-30
- CountryChina
- Language:Chinese
-
Abstract:
Dendrimers, a special class of synthetic polymers known for their well-defined ramified structures and unique multivalent cooperativity, hold great promise for various biomedical applications. However, preparation of defect-free dendrimers of high-generation on a large scale remains challenging because of the tedious and time-consuming synthesis as well as difficult purification. To overcome these limitations, an alternative strategy based on self-assembling approach has been developed to construct supramolecular dendrimers using small amphiphilic dendrimer-building units. By virtue of the amphiphilic nature, these small dendrimer-building units self-assemble and form large non-covalent supramolecular dendritic structures that mimic high-generation covalent dendrimers. Here, we present a brief overview of the supramolecular dendrimers developed in our group for the delivery of nucleic acid therapeutics, anticancer drug and imaging agents.
