Progress of research on immune escape mechanism of coronavirus
10.11665/j.issn.1000-5048.20210101
- VernacularTitle:冠状病毒免疫逃逸机制研究进展
- Author:
Ronghua WANG
1
;
Zhihui ZHENG
;
Ying ZHANG
;
Rui MIN
;
Ying ZHU
;
Pinghu ZHANG
Author Information
1. 扬州大学医学院转化医学研究院
- Publication Type:Journal Article
- Keywords:
corornavirus;
COVID-19;
novel coronavirus pneumonia;
host innate immune response;
immune escape;
immunosensor;
interferon;
cytokines
- From:
Journal of China Pharmaceutical University
2021;52(1):1-9
- CountryChina
- Language:Chinese
-
Abstract:
Coronavirus is an important pathogen of humans and animals. Among them, the novel coronavirus disease (COVID-19) breaking out in 2019 has brought a fatal threat to human health. The host"s innate immune response is the host"s first line of defense against pathogen invasion, but an excessive immune response can also aggravate viral infection and pathological damage. The immune escape of coronavirus is a critical pathogenic mechanism causing death. This work mainly reviews the pathogenic mechanism of coronavirus immune escape from several aspects such as host immunosensor, interferon, cytokine and coronavirus antagonizing host immune response, which provide a theoretical reference for the development of anti-coronavirus drugs.
