Efficacy and safety of Bifidobacteria in preventing caries: a systematic review and meta-analysis
10.12016/j.issn.2096-1456.2021.04.004
- Author:
HAO Siyuan
1
;
WANG Jiahe
1
;
ZHANG Xiaoqi
1
;
ZOU Jing
2
;
WANG Yan
2
Author Information
1. State Key Laboratory of Oral Diseases, National Clinical Research for Oral Diseases, West China Hospital of Stomatology, Sichuan University
2. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University
- Publication Type:Journal Article
- Keywords:
caries;
Bifidobacterium;
Streptococcus mutans;
Lactobacilli;
systematic review;
Meta-analysis;
randomized controlled trial
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(4):241-248
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the efficacy and safety of Bifidobacteria in preventing caries.
Methods :Databases including PubMed, Embase, The Cochrane Library, Web of Science, Scopus, Clinicaltrials. gov, CNKI, WanFang Data and VIP were electronically searched from inception to April 2020 to collect randomized controlled trials of Bifidobacterium for caries. Meta-analysis was performed using Revman 5.4 software.
Results: In total, 10 randomized controlled trials (RCT) of 518 patients, including 262 in the test group and 256 in the control group, were included. Meta-analysis results reveal no statistically significant differences in salivary Streptococcus mutans counts (SMD=-0.31, 95%CI -0.66 to 0.04, P=0.08) (RR=0.53, 95%CI 0.17 to 1.66, P=0.28) and salivary Lactobacilli counts (SMD=-0.07, 95%CI -0.39 to 0.26, P=0.69) (RR=0.87, 95%CI 0.59 to 1.29, P=0.50). No statistical differences in the counts of Streptococcus mutans and Lactobacillus counts were noted in dental plaque, and no statistical difference in the occurrence of caries in deciduous teeth. Three of the 10 RCTS included in this study did not report adverse events, 5 had no adverse reactions, and 2 reported gastrointestinal discomfort.
Conclusion: Current evidence suggests that Bifidobacteria do not effectively reduce Streptococcus mutans counts and Lactobacillus counts in saliva and dental plaque, or reduce the occurrence of caries in deciduous teeth. The safety of this treatment also requires further investigation.
- Full text:双歧杆菌预防龋病有效性和安全性的系统评价与Meta分析.pdf
