Association between total cholesterol and type 2 diabetes: a prospective cohort study
10.16462/j.cnki.zhjbkz.2020.04.002
- Author:
Yuan LU
1
;
Huan-le LIU
;
Yun-tao MA
;
Xiao-yu DAI
;
Zhi-heng WANG
;
Yan-xun LIU
Author Information
1. Department of Biostatistics，School of Public Health，Cheeloo College of Medcine，Shandong University
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes;
Total cholesterol;
Longitudinal data;
Generalized estimating equation
- From:
Chinese Journal of Disease Control & Prevention
2020;24(4):380-383,479
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between total cholesterol and type 2 diabetes ( T2DM) ． Methods Non－diabetic people who aged 20 to 90 years at the baseline and who had physical examination more than 2 times were screened． Comparisons of the baseline characteristics were conducted with Student－t test or Pearson chi－square test． Generalized estimating equation ( GEE) was used to analyze the effect of total cholesterol of quantiles groups ( 2．10－ mmol /L，4．16－ mmol /L，4．76－ mmol /L and 5．42 －13．29 mmol /L) to type 2 diabetes． Results The cohort with an average age of 3．53 years per person in- cluded 12 928 subjects and 45 626 person－years． During the follow－up，447 cases of new－onset diabetes occurred and the incidence density was 9. 80‰． The high incidence of type 2 diabetes increased with the increase of total cholesterol． After adjusting the factors including age，high density lipoprotein，hypertension and obesity，based on the 2. 10－ mmol /L group，the relative risk ( RR) of the 4. 16－ mmol /L，4. 76－ mmol/L and 5. 42－13. 29 mmol /L group were 1. 24( 95% CI: 0. 83－1. 86) ，1. 75 ( 95% CI: 1. 19－2. 56) and 3. 60( 95% CI: 2. 51－5. 17) ，respectively． Conclusions Total cholesterol is associated with type 2 diabetes，and as the total cholesterol increases，the risk of developing type 2 diabetes increases．
