Advance of neurodegeneration in diabetic retinopathy
10.3980/j.issn.1672-5123.2021.3.12
- VernacularTitle:神经元退行性病变在糖尿病视网膜病变中的研究进展
- Author:
Meng-Meng Jiang
1
,
2
,
3
Author Information
1. 1Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
2. 2Department of Ophthalmology, Shanghai General Hospital(Shanghai First People'
3. s Hospital), Shanghai Jiao Tong University, Shanghai 200080, China
- Publication Type:Review
- Keywords:
diabetic retinopathy;
neurodegeneration;
neuronal apoptosis;
reactive gliosis;
microangiopathy
- From:
International Eye Science
2021;21(3):442-445
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR), one of the most common complications of diabetes, has been widely reported as microangiopathy. However, retinal neurodegeneration was reported to occur early in DR and played a significant role in DR progression. Retinal neurodegeneration in DR was characterized as neuronal apoptosis and reactive gliosis. The mechanisms for its pathogenesis include hyperglycemia, oxidative stress, glutamate excitotoxicity, and inflammation etc. Furthermore, retinal neurodegeneration has a close relationship with the microangiopathy in the pathogenesis of DR.
- Full text:202103012.pdf
