Mechanism of action of bile acid-farnesoid X receptor-intestinal microecological axis in the development of liver failure and liver regeneration
DOI:10.3969/j.issn.1001-5256.2021.02.049
- VernacularTitle:胆汁酸-法尼醇核受体R-肠道微生态轴在肝衰竭发生及肝再生中的作用机制
- Author:
Yanyan CHEN
1
;
Yanmei LAN
;
Minggang WANG
;
Dewen MAO
Author Information
1. Department of Basic Medicine, Hunan Traditional Chinese Medical College, Zhuzhou, Hunan 412000, China
- Publication Type:Research Article
- Keywords:
Liver Failure;
Liver Regeneration;
Bile Acid;
Farnesol Receptor R;
Gastrointestinal Microbiome
- From:
Journal of Clinical Hepatology
2021;37(2):480-484
- CountryChina
- Language:Chinese
-
Abstract:
Liver failure is a common critical medical disease, and extensive liver cell necrosis within a short period of time exceeds the regeneration capacity of liver cells and thus results in an extremely high fatality rate. Promotion of effective liver regeneration is the key to antagonizing liver failure. Recent studies have shown that bile acid, farnesoid X receptor (FXR), and intestinal microecology play an important role in liver failure and liver regeneration. This article reviews the association between bile acid, FXR, and intestinal microecology and their role in liver failure and liver regeneration, so as to provide new ideas for the treatment of liver failure in clinical practice.
