Systematic Evaluation of Clinical Efficacy and Safety of Traditional Chinese Medicine for Post Stroke Cognitive Impairment
10.13422/j.cnki.syfjx.20201151
- VernacularTitle:中药治疗卒中后认知障碍疗效和安全性的系统评价
- Author:
Wei SHEN
1
;
Zi-xiu ZENG
1
;
Xiang-lan JIN
2
;
Yan LU
3
;
Ying WANG
1
;
Shi-xin LI
1
;
Shi-jiao ZHAO
1
;
Hui MEN
1
;
Ming-quan LI
4
;
Jian-jun ZHAO
4
;
Hu ZHANG
5
;
Zhen-yao WANG
5
;
Jian YANG
6
;
Xin XIONG
6
;
Shang-zhen YU
7
;
Qing SHI
7
;
Yun-ling ZHANG
3
Author Information
1. Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China
2. Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
3. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
4. Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China
5. Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine (TCM), Beijing 101300, China
6. Chongqing TCM Hospital, Chongqing 400011, China
7. Jiangmen Wuyi Hospital of TCM, Jiangmen 529000, China
- Publication Type:Research Article
- Keywords:
post stroke cognitive impairment (PSCI);
traditional Chinese medicine;
randomized controlled trial (RCT);
Meta analysis;
cognitive function level;
activity of daily living;
neurological impairment
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(11):185-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of traditional Chinese medicine (TCM) in the treatment of post stroke cognitive impairment (PSCI). Method:Seven databases, including CNKI, WanFang, VIP, CBM, PubMed, The Cochrane library and ClinicalTrials.gov, were electronically searched for relevant randomized controlled trials (RCTs) of TCM in the treatment of PSCI. The Cochrane risk of bias assessment tool was used to evaluate the methodological quality of the included studies, descriptive analysis was carried out on the included studies, and the Meta quantitative analysis was carried out with RevMan 5.3 software. Result:A total of 16 RCTs were included with 1 296 participants, and they were assigned to the intervention group (n=649) and the control group (n=647). The results showed that TCM combined with western medicine group and TCM group were better than western medicine group in improving the scores of Montreal Cognitive Assessment (MoCA), Mini-mental State Examination (MMSE), Barthel Index (BI), Activity of Daily Living (ADL), Chinese stroke scale (CSS) and National Institutes of Health stroke scale (NIHSS) of PSCI patients, and no serious adverse events were observed. Conclusion:TCM has potential advantages in improving the cognitive function of patients with PSCI, and it also has certain efficacy in improving the daily living ability and neurological impairment symptoms, and no serious adverse events have been observed. Due to the low quality of methodology included in the studies, in order to provide reliable basis for clinical decision-making, high-quality of RCTs are still needed to study the efficacy and safety of TCM for PSCI.
