Effect of Three Chinese Herbs Processed with Different Proportions of Glycyrrhizae Radix et Rhizoma on Pharmacokinetics of Dapsone in Rats
10.13422/j.cnki.syfjx.20200651
- VernacularTitle:3味中药经不同比例甘草炮制后对氨苯砜在大鼠体内药代动力学的影响
- Author:
Zai-xing CHENG
1
;
Zhen-zhen CAI
2
;
Li-hong LIN
3
;
Bao-yu ZHENG
1
;
Hong CHEN
1
Author Information
1. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
2. Community Healthcare Center of Songyu Stree in Haicang District, Xiamen 361026, China
3. Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co. Ltd., Guangzhou 510515, China
- Publication Type:Research Article
- Keywords:
Morindae Officinalis Radix;
Euodiae Fructus;
Polygalae Radix;
Glycyrrhizae Radix et Rhizoma;
processing;
cytochrome P450 enzyme;
dapsone
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(8):148-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective::To investigate the processing purpose of Morindae Officinalis Radix (MO), Euodiae Fructus (EF) and Polygalae Radix (PR) processed by Glycyrrhizae Radix et Rhizoma (Gly). Method::The content of dapsone in rat plasma was determined by high performance liquid chromatography (HPLC), the mobile phase was acetonitrile (A)-water (B) for gradient elution (0-5 min, 10%-25%A; 5-20 min, 25%A) and detection wavelength was set at 292 nm. PK Solution 2.0 software was used to simulate pharmacokinetic parameters. Result::Within 300 min after dapsone was administrated, compared with the control (CTL) group, the elimination of dapsone was slowed down and its plasma concentration was increased in the unprocessed product of MO (UMO) group. The elimination of dapsone was accelerated and its peak concentration (Cmax) was decreased in the processed products of MO with Gly (GMO) groups, and they had positive correlation with proportion of Gly in GMO. Compared with the CTL group, the elimination of dapsone was slowed down, and its plasma concentration was increased and its peak time (Tmax) was postponed in the unprocessed product of EF (UEF) group, while their Cmax and Tmax were changed in the processed products of EF with Gly (GEF) groups. Compared with the CTL group, the elimination of dapsone was slowed down and its plasma concentration was increased in the unprocessed product of PR (UPR) group, while the elimination was accelerated and its plasma concentration was decreased in the processed products of PR with Gly (GPR) groups. Conclusion::The elimination of dapsone is slowed down in rats administered with UMO, UEF and UPR, while its elimination is accelerated in rats administered with the processed products of these three herbs with different proportions of Gly. Among the proportions, effect of processed products of these three herbs with 100∶6 (ratio of unprocessed product-Gly) on pharmacokinetics of dapsone is not significant.
