Effect of Traditional Chinese Medicine and Its Active Ingredients on Cardiovascular Disease Based on Nrf2/HO-1 Signaling Pathway
10.13422/j.cnki.syfjx.20200405
- VernacularTitle:基于Nrf2/HO-1信号通路的中药及其有效成分抗心血管疾病作用研究进展
- Author:
Xiang WANG
1
;
Jia-jia MO
2
;
Peng ZHOU
1
;
Hui SHI
1
;
Jin-ling HUANG
1
Author Information
1. Anhui University of Chinese Medicine, Hefei 230038, China
2. Hefei Medical and Pharmaceutical Co. Ltd., Hefei 230601, China
- Publication Type:Research Article
- Keywords:
nuclear factor erythroid-2-related factor 2/heme oxygenase 1(Nrf2/HO-1);
traditional Chinese medicine;
active ingredients;
cardiovascular disease
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(10):227-234
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease is the leading cause of death in China. Due to its great individual differences in genetic background, pathogenesis and disease development trend, the survival risk rate after standardized western medicine treatment under the guidance of the current guidelines remains high. Traditional Chinese medicine(TCM) has unique multiple-target, multiple-pathway and multiple-layer advantages, which can effectively make up for shortcomings of western medicine. Therefore, it has been widely used in the treatment of cardiovascular diseases. Oxidative stress is one of the important causes of cardiovascular diseases. Nuclear factor erythroid-2-related factor 2(Nrf2) is the central regulator of this reaction. When being activated, it can transfer to the nucleus and initiate signaling in the downstream pathway, thus playing an anti-oxidative stress role. As one of the most important endogenous protection systems in the body, the Nrf2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway is the most classical approach for Nrf2 in playing roles. There have been certain achievements in studying and clarifying TCM by regulating this pathway to treat cardiovascular diseases using modern molecular biology and other methods. Based on this, this paper summarized the relationship between Nrf2/HO-1 signaling pathway and cardiovascular diseases, then concluded and analyzed the mechanism and pharmacological effects of TCM and its active ingredients in Nrf2/HO-1 signaling pathway on different cardiovascular diseases, involving active ingredients of TCM, TCM pairs active ingredients, TCM extracts and TCM formula. This paper provides a theoretical reference for the development and utilization of anti-cardiovascular drugs.
