Chemical Constituents from Stems of Zanthoxylum bungeanum
10.13422/j.cnki.syfjx.20201111
- VernacularTitle:花椒茎的化学成分Ⅱ
- Author:
Jing-rong LOU
1
;
Zhong-fei ZHENG
2
;
Ying LI
2
;
Chao QI
1
;
Xue CUI
1
;
Qing-qiang YAO
2
Author Information
1. School of Medicine and Life Sciences, University of Ji' nan, Shandong Academy of Medical Sciences, Ji'nan250200, China
2. Institute of Materia Medica, Shandong Academy of Medical Sciences, Key Laboratory for Biotech-Drugs Ministry of Health, Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Ji'nan250062, China
- Publication Type:Research Article
- Keywords:
Zanthoxylum bungeanum stems;
alkaloid;
coumarin;
lignans;
ethanol extracts;
pseudocolumbamine;
3, 4, 5-trimethoxycinnamylalcohol;
24-propylcholesterol
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(10):141-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective::To isolate and identify the chemical constituents from the 95%, 75%ethanol extracts of the stems of Zanthoxylum bungeanum. Method::The 25 kg stems of Z. bungeanum were extracted with 95%, 75%ethanol for three times, and the combined filtrates were concentrated under vacuum to get the extracts. The 95%extracts were then extracted by petroleum ether, dichloromethane, ethyl acetate and n-butanol successively to obtain corresponding fractions. Such fractions and 75%extracts were isolated and purified by silicagel, Sephadex LH-20, ODS, preparation HPLC and recrystallization to obtain compounds. Their structures were identified by mass spectroscopy (MS), and nuclear magnetic resonance (NMR). Result::Sixteen compounds were isolated from the stems of Z. bungeanum and identified as dictamnine(1), decarine(2), zanthobungeanine(3), pseudocolumbamine(4), skimmianine(5), norchelerythrine(6), osthenol(7), dimethylfraxetin(8), 3, 4, 5-trimethoxycinnamylalcohol(9), asarinin(10), yangambin(11), syringaresinol(12), ashantin(13), bis(2-ethylhexyl) benzene-1, 2-dicarboxylate(14), 24-propylcholesterol(15), and sucrose(16). Conclusion::Compounds pseudocolumbamine(4), 3, 4, 5-trimethoxycinnamylalcohol(9), and 24-propylcholesterol(15)were isolated from the genus of Zanthoxylum for the first time and compounds dictamnine(1), osthenol(7), dimethylfraxetin(8), asarinin(10), yangambin(11), syringaresinol(12), ashantin(13), and bis(2-ethylhexyl) benzene-1, 2-dicarboxylate(14)were isolated from this plant for the first time.
