Effect of Modified Longdan Xiegantang in Treatment of Anal Sinusitis Patients with Syndrome of Interior Dampness-heat and on Immune Response, Oxidative Stress
10.13422/j.cnki.syfjx.20191624
- VernacularTitle:龙胆泻肝汤加减治疗肛窦炎湿热内蕴证的疗效及对免疫应答、氧化应激的影响
- Author:
Ning ZHANG
1
;
Xiao-li ZHOU
2
;
Shuai LIU
3
Author Information
1. Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China
2. The Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450008, China
3. Zhengzhou Yihe Hospital, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
anus sinusitis;
modified Longdan Xiegantang;
inflammation;
oxidative stress;
immune function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(3):78-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective::To explore the effect of modified Longdan Xiegantang in treatment of anal sinusitis patients with syndrome of interior dampness-heat and on immune response, oxidative stress. Method::A total of 80 cases of anal sinusitis patients with syndrome of interior dampness-heat treated in our hospital from May 2017 to May 2018 were randomly divided into two groups, with 40 cases in each group. The control group was treated by enema with Metronidazole injection combined with gentamicin sulfate injection. In addition to the therapy of the control group, the treatment group was also given modified Longdan Xiegantang. The symptoms and signs score, interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), procalcitonin (PCT), CD3+, CD4+, CD8+, immunoglobulin A(IgA), IgG, IgM, IgE, SOD, propylene glycol (MDA) levels of two groups were observed before and after treatment, and the curative effect, reactions and relapse were observed. Result::The clinical efficacy of treatment group was significantly better than that of control group, and the rank-sum test showed statistically significant differences (Z=1.981, P<0.05). After treatment, the scores of symptoms, such as anal distension and pain, and signs, such as anal sinus tenderness, hyperemia and edema in the treatment group were lower than those in control group (P<0.05). The levels of TNF-α, PCT, IL-2, IL-6 and MDA in treatment group were lower than those in control group (P<0.05). The levels of IL-4, IL-10, IFN-γ and SOD in treatment group were higher than those in control group (P<0.05). The recurrence rate was 5.13%in treatment group, and 21.05%in control group, indicating a significant difference (χ2=4.319, P<0.05). Conclusion::Modified Longdan Xiegantang is effective in treating syndrome of interior dampness-heat anal sinusitis. It can effectively relieve symptoms, regulate pro-inflammatory/anti-inflammatory balance and Th1/Th2 balance, improve cellular immune function and humoral immune function, inhibit oxidative stress response, and reduce recurrence rate, with a high safety.
