Effect of Modified Taohe Chengqitang Combined with Colon Hydrotherapy on Inflammatory Factors and Insulin Resistance in Patients with Severe Nonalcoholic Fatty Liver Disease
10.13422/j.cnki.syfjx.20200325
- VernacularTitle:桃核承气汤加减结肠水疗对痰热瘀结型重度非酒精性脂肪肝炎症因子及胰岛素抵抗的影响
- Author:
Jian-hong LI
1
;
Qing-hua HUANG
1
;
Xiao-ai MO
1
;
Teng-yu QIU
1
;
Jian REN
1
;
Lei ZHANG
1
;
Kai-ping JIANG
1
Author Information
1. Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China
- Publication Type:Research Article
- Keywords:
modified Taohe Chengqitang;
nonalcoholic fatty liver disease (NAFLD);
tumor necrosis factor-α (TNF-α);
interleukin-6 (IL-6);
insulin resistance (IR)
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(3):37-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective::To define the clinical efficacy of modified Taohe Chengqitang combined with colon hydrotherapy in patients with severe nonalcoholic fatty liver disease (NAFLD) accompanied by phlegm-heat stagnation syndrome and its mechanism. Method::Totally 100 patients with severe NAFLD by phlegm-heat stagnation syndrome were enrolled in the study.They were all given Shanzha Xiaozhi capsule.According to the random number table, the patients were randomly divided into the observation group (50 patients, colon hydrotherapy combined with traditional Chinese medicine) and the control group (50 patients, Shanzha Xiaozhi capsule alone). The observation period was 4 weeks.The therapeutic effect of colon hydrotherapy was verified through determinations of the liver function, blood lipid, insulin resistance index (IRI), controlled attenuation parameter (CAP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) before and after treatment.The mechanism of colon hydrotherapy combined with modified Taohe Chengqitang was preliminarily analyzed based on changes of IR, TNF-α and IL-6. Result::Alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptadase (γ-GT), total cholesterol (TCH), triglyceride (TG), fasting plasma glucose (FPG), fasting insulins (FINS), IRI, CAP, TNF-αand IL-6 of NAFLD patients in both of two groups were significantly lower than those before treatment (P<0.01). ALT, AST, γ-GT, TCH, TG, FPG, IRI, CAP, TNF-α and IL-6 in observation group were significantly lower than those in the control group after treatment (P<0.01). FINS in observation group was significantly lower than that in the control group (P<0.05). Conclusion::Colon hydrotherapy combined with modified Taohe Chengqitang is an effective method for treating NAFLD accompanied by phlegm-heat stagnation syndrome.Its mechanism may be mainly correlated with the reduction of IRI, serum TNF-α and IL-6.The course of colon hydrotherapy, the therapeutic mechanism and the long-term efficacy need to be further studied in the future.
