Effect and Mechanism of Modified Banxia Xiexintang on Depression During Perimenopause
10.13422/j.cnki.syfjx.20192134
- VernacularTitle:半夏泻心汤加减治疗围绝经期抑郁症的机制作用
- Author:
Jia PAN
1
;
Qiang HU
2
;
Jun-jun YANG
3
;
Ben-yan SONG
2
;
Nan NING
1
;
Li HUANG
1
;
Jie LIU
1
;
Ya-ou LIU
1
;
Yan-li DENG
1
;
Ya YU
1
;
Li-min LI
1
Author Information
1. Sichuan Academy of Traditional Chinese Medicine, Chengdu 610041, China
2. Affiliated Hospital of Panzhihua University, Panzhihua 617000, China
3. Sichuan Integrated Traditional Chinese and Western Medicine Hospital, Chengdu 610024, China
- Publication Type:Research Article
- Keywords:
perimenopausal depression;
liver depression and spleen deficiency syndrome;
Banxia Xiexintang;
quality of life;
5-hydroxytryptamine(5-HT);
pro-inflammatory factor
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(3):15-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective::To observe the effect of modified Banxia Xiexintang on depression during perimenopause, in order to study itseffecton 5-hydroxytryptamine (5-HT) and proinflammatory factors. Method::One hundred and thirty-nine patients were randomly divided into control group (69 cases) and observation group (70 cases) by random number table.Patients in control group got tibolone tablets, 2.5 mg/time, 1 time/day, and paroxetine hydrochloride tablets, 20 mg/time, 1 time/day.In addition to the therapy in control group, patients in observation group were added with modified Banxia Xiexintang, 1 dose/day.The course of treatment was 8 weeks.And before and after treatment, Hamilton depression scale for-17 items (HAMD-17), Zung's self-rating depression scale (SDS), hamilton anxiety scale (HAMA), improvement Kupperman(KI), liver depression and spleen deficiency syndrome, menopause-specific quality of life questionnaire (MENQOL) and treatment emergent symptom scale (TESS) were scored, and levels of 5-HT, rain-derived neurotrophic factor (BDNF), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were detected. Result::After treatment, scores of HAMD-17 and SDS in observation group were lower than those in control group (P<0.01). And the effect on trea depression in observation group was better than that in control group (Z=2.074, P<0.05). The degree of depression in observation group was ligher than that in control group (Z=2.157, P<0.05). And scores of HAMA, KI and liver depression and spleen deficiency syndrome were lower than those in control group (P<0.01). The severity of perimenopausal syndrome was ligher than that in control group (Z=2.046, P<0.05). And scores of vasomotor symptoms and psychological symptoms of MENQOL scale and the total scores were lower than those in control group (P<0.05). Levels of 5-HT and BDNF were higher than those in control group (P<0.01), while levels of IL-1β, TNF-α and TESS were lower than those in control group (P<0.01). Conclusion::In addition to theroutine western medicine, modified Banxia Xiexintang can alleviate the severity of depression, release the symptoms of depression, anxiety and perimenopausal syudrome(PMS), improve the quality of life, inhibit pro-inflammatory factors, and enhance the expressions of 5-HT and BDNF, with no adverse event.
