Mechanism of Traditional Chinese Medicine and Its Compound on Liver Fibrosis
10.13422/j.cnki.syfjx.20200106
- VernacularTitle:中药及其复方抗肝纤维化作用机制的研究进展
- Author:
Chao LYU
1
;
De-wen MAO
2
;
Qing-lan SHI
2
;
Qian QIN
1
;
Wen-jie BAI
1
Author Information
1. Guangxi University of Chinese Medicine, Nanning 530222, China
2. The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine;
liver fibrosis;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(4):242-250
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic fibrosis refers to the pathological process of abnormal proliferation of intrahepatic connective tissue caused by various pathogenic factors, resulting in the excessive accumulation of extracellular matrix (ECM) in the liver and the formation of fibrous scar. Its continuous deterioration will gradually develop into liver cirrhosis, liver failure, liver cancer and other serious liver diseases. Because liver fibrosis and early liver cirrhosis can be reversed, it is very important to control the reversible process of liver fibrosis for the prevention and treatment of liver cirrhosis and liver cancer. In recent years, it has been found that traditional Chinese medicine(TCM) has the characteristics of multi-target, less toxic and side effects and good effect in the treatment of liver fibrosis. In this paper, the mechanism of anti-hepatic fibrosis of TCM and its compound was summarized. TCM can regulate transforming growth factor-β (TGF-β), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF) and other growth factors to inhibit the activation of (HSCs) and induce the apoptosis of activated HSCs, promote the expression of adiponectin and inhibit the secretion of leptin, inhibit the inflammatory reaction of liver, resist oxidant stress, inhibit the capillarization of hepatic sinusoidal endothelial cells, so as to effectively prevent the progress of liver fibrosis. Therefore, TCM can inhibit the development of liver fibrosis through multi-mechanism and multi-level, and is one of the important means to treat liver fibrosis.
