Mechanism of Traditional Chinese Medicine in Treating Drug-resistant Bacterial Infection
10.13422/j.cnki.syfjx.20201624
- VernacularTitle:中药治疗耐药菌感染作用机制研究进展
- Author:
Li-yang JIA
1
;
Dong DENG
1
;
Li-hua SUN
1
;
Jian-hong BU
2
;
Zhen-yi CHEN
3
;
Miao-qing YE
4
;
Wen ZHANG
1
;
Bang-jiang FANG
1
Author Information
1. Longhua Hospital,Shanghai University of Traditional Chinese Medicine (TCM)，Shanghai 200032,China
2. Shanghai Hospital of TCM，Shanghai 200071,China
3. Henan Province Hospital of TCM, Zhengzhou 450002,China
4. Shanxi Province Hospital of TCM,Xi'an 710000,China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine;
antibacterial;
bacterial resistance;
drug-resistant bacterial infection
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(16):228-234
- CountryChina
- Language:Chinese
-
Abstract:
The discovery of penicillin has effectively controlled the infection caused by Gram-positive bacteria. Afterwards, the research and development of antibacterial drugs has entered the golden age, and made a great contribution to human health. However, in recent years, with the increasing use of antibiotics around the world, pathogenic bacteria drive gene mutation to obtain drug resistance to ensure its survival advantage, and promote the transfer of drug-resistant genes, resulting in a sharp increase of drug-resistant bacteria. In addition, the current development speed of new antibiotics is far slower than the growth and spread speed of drug-resistant bacteria, which makes the drug-resistant crisis more serious and becomes one of the biggest threats to the global community. Compared with the same type of bacterial infection, drug-resistant bacterial infection has the characteristics of complexity and refractoriness, which causes worse clinical outcome and higher risk of death in patients, and brings severe challenges to clinical work. If the trend of bacterial drug resistance is not controlled, the crisis of no drug available will come. Therefore, it is urgent to explore effective alternative means to fight against bacterial drug resistance and reduce the harm of drug-resistant bacterial infection. Traditional Chinese medicine（TCM） has unique advantages in the treatment of infectious diseases. Compared with modern antibacterial drugs, it has the characteristics of wide sources, rich active ingredients, and is not easy to produce drug resistance. It may be an important source for screening and developing new anti-infective drugs. Therefore, it is promising to develop and utilize TCM to solve the problem of drug-resistant bacteria infection. This paper will review relevant studies in recent years in terms of interfering with the biochemical metabolism of drug-resistant bacteria to directly inhibit or kill drug-resistant bacteria, improving bacterial drug resistance to indirectly inhibit bacteria and kill bacteria, and maintaining the balance of the body and regulating the treatment of drug-resistant bacteria infection as a whole, so as to provide references for guiding clinical medication and research and development of new traditional Chinese medicines.
