Effect and Mechanism of Traditional Chinese Medicine on Prevention and Treatment of Pathological Scar
10.13422/j.cnki.syfjx.20201707
- VernacularTitle:中药防治病理性瘢痕的作用及机制研究进展
- Author:
Zi-li SUN
1
;
Si-yu LIU
1
;
Ming-li ZOU
1
;
Yi FENG
2
;
Yong DU
3
;
Min-lie YANG
3
;
Shun YU
3
;
Zheng-dong YUAN
3
;
Jun-jie WU
3
;
Guo-zhong LYU
1
;
Feng-lai YUAN
1
Author Information
1. Nanjing University of Traditional Chinese Medicine, Nanjing 210023, China
2. Yangzhou University, Yangzhou 225001, China
3. Affiliated Hospital of Jiangnan University, Wuxi 214043, China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine;
pathological scar;
wound healing;
fibroblast;
extracellular matrix
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(17):225-234
- CountryChina
- Language:Chinese
-
Abstract:
Pathological scar is a kind of skin fibrotic disease caused by abnormal wound healing, including hypertrophic scar and keloid. Pathological scar may lead to aesthetic flaws, limb dysfunction and local discomfort in patients. Due to the complexity of the wound healing process, the formation of scar is affected by many factors. In addition to traditional surgical, laser, cryostatic and hormone injection methods for the treatment of pathological scar, there are new therapies, such as mesenchymal stem cell therapy, fat transplantation, interferon, and botulinum toxin. They are widely used in clinical practice, but with such problems as high prices and many side effect. Traditional Chinese medicine (TCM) has a long history in treating pathological scar. In recent years, in vivo and in vitro studies have shown that TCM has effect IN reducing inflammation, inhibiting fibroblast proliferation, regulating fibroblast activation and migration, inducing fibroblast apoptosis and autophagy, promoting the degradation of extracellular matrix (ECM) and reducing angiogenesis in general. Besides, TCM has also a certain regulatory role in the signaling pathways, such as transforming growth factor-β1 (TGF-β1)/Smads, phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and sonic hedgehog (Shh). There are still some contradictions in relevant studies, and specific mechanisms remain to be further improved. This paper summarizes the study content, findings and relevant mechanisms of different TCM based on in vivo and in vitro experiments, analyzes the advantages and disadvantages of TCM in the prevention and treatment of pathological scar, and its prospects in clinical application, so as to provide basis and ideas for future scar studies.
