Relationship Between Immune Checkpoint and Autoimmune Disease
- VernacularTitle:免疫共刺激分子与自身免疫性疾病的研究进展
- Author:
Qing-sen RAN
1
;
Qi LI
1
;
Li LIU
1
;
Li-dong SUN
1
;
Qing YANG
1
;
Yu-jie LI
1
;
Ying CHEN
1
;
Ya-jie WANG
1
;
Xiao-gang WENG
1
;
Wei-yan CAI
1
;
Xiao-xin ZHU
1
Author Information
- Publication Type:Research Article
- Keywords: immune homeostasis; co-stimulatory molecules; autoimmune disease
- From: Chinese Journal of Experimental Traditional Medical Formulae 2020;26(18):188-195
- CountryChina
- Language:Chinese
- Abstract: The normal immune system has the ability to distinguish between "self" and "non-self". Because of its dynamic balance of "immune activity-immune tolerance", it will produce immune response to the non-self antigen, but with no response or weak response to the self-antigen. However, if the balance was broken, T cell in the abnormal immune activation state will respond continually to the self-antigen, with an abnormal immune response, which caused autoimmune disease. Pathologically, "invalid" immune recognition and immune response become the main causes for autoimmune diseases. Co-stimulatory molecule is an important link between Attach antigen presenting cells（APC） and immune cells (T cell and B cell). Studies have proved that excessive co-stimulation and/or insufficient co-inhibition could cause detect of self-tolerance and induce autoimmunity. Although co-stimulatory and co-inhibitory pathways have a significant impact on all ADS, this paper focuses on their effect on two systemic autoimmune diseases [systemic lupus erythematosus （SLE） and rheumatoid arthritis（RA）] and two organ-specific autoimmune diseases [multiple sclerosis （MS） and type 1 diabetes （T1DM）], in order to discuss the pathogenesis and relationship between co-stimulatory molecules and autoimmune diseases.
