Regulatory Mechanism of Traditional Chinese Medicine in Promoting Angiogenesis After Cerebral Infarction Based on STAT3/miRNA Feedback Loop
10.13422/j.cnki.syfjx.20201862
- VernacularTitle:基于STAT3/miRNA反馈环路探讨中医药促脑梗死后血管新生的调控机制
- Author:
Ren-yi YANG
1
;
De-sheng ZHOU
2
;
Xin-ying FU
1
;
Si-yang YAN
1
;
Cui-lan GONG
3
;
Qiang MA
1
;
Li-juan LIU
2
Author Information
1. Hunan University of Chinese Medicine, Changsha 410208, China
2. The First Hospital Affiliated to Hunan University of Chinese Medicine, Changsha 410007, China
3. Changde Hospital of Hunan University of Chinese Medicine, Changde 415000, China
- Publication Type:Research Article
- Keywords:
cerebral infarction;
angiogenesis;
signal transduction and transcriptional activators3 (STAT3);
miRNA;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(20):221-228
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral infarction is a clinical disease with corresponding neurological symptoms caused by cerebral ischemia and hypoxia caused by cerebral blood supply disorder. It is one of the most common cerebrovascular diseases and a serious threat to human health. The prevention and treatment of cerebral infarction has an important social significance. Angiogenesis is the key starting point for medical treatment of cerebral infarction, and signal transduction and transcriptional activators (STAT)/hypoxia inducing factor-1(HIF-1)/vascular endothelial growth factor (VEGF) pathway are important pathways to mediate angiogenesis after cerebral infarction. This paper took the angiogenesis as the starting point and the upstream molecules of STAT/HIF-1/VEGF signal pathway STAT3 and miRNA as the main study objects, and comprehensively discussed the results of chip sequencing, experimental research, traditional Chinese medicine (TCM) pathogenesis and TCM treatment. Based on the regulatory mode of "TF-miRNA" and the idea of "micro-whole", it is suggested that under the guidance of the basic theory of TCM, cubic compound prescriptions of TCM and its active components might activate the STAT/HIF-1/VEGF signal pathway through STAT3/miRNA feedback loop to promote angiogenesis after cerebral infarction, which puts forward a deep molecular mechanism and new direction for the treatment of cerebral infarction with TCM.
