Optimization of Processing Technology of Salt-processed Products of Plantaginis Semen Based on Response Surface Method and AHP-CRITIC Mixed Weighting Method and Investigation of Its Diuretic Effect
10.13422/j.cnki.syfjx.20201246
- VernacularTitle:基于AHP-CRITIC混合加权法和响应面法的盐车前子炮制工艺优选及其利尿作用考察
- Author:
Chao LI
1
;
Huan YU
1
;
Rou WEN
1
;
Li-ping YAN
1
;
Qian-feng GONG
1
;
Ling-yun ZHONG
1
;
Jin-lian ZHANG
1
Author Information
1. School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China
- Publication Type:Research Article
- Keywords:
salt-processed products of Plantaginis Semen;
processing technology;
analytic hierarchy process (AHP);
criteria importance through intercrieria correlation (CRITIC);
response surface method;
pharmacodynamics;
diuresis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(20):124-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the processing technology of salt-processed products of Plantaginis Semen with the specific process parameters, and verify the obtained processing technology by pharmacodynamic research, so as to provide experimental basis for the standardized production and quality control of this decoction pieces. Method:Taking composite score of appearance character score, dry extract yield and contents of three components (geniposidic acid, acteoside and isoacteoside) as index, the analytic hierarchy process (AHP)-criteria importance through intercrieria correlation (CRITIC) mixed weighting method was used to determine the weight coefficient of each index. Based on single factor tests, the response surface method was used to investigate the effects of frying time, frying temperature, salt amount and water amount on the processing technology of salt-processed products of Plantaginis Semen, and the processing technology was verified by diuretic experiment with furosemide tablets as the positive drug (administration dose of 0.01 g·kg-1). Result:The weight coefficients of geniposidic acid content, acteoside content, appearance character score, isoacteoside content and dry extract yield were 0.319, 0.193, 0.207, 0.273 and 0.008, respectively. The optimal process parameters were as following：fried at 150-180 ℃ for 10 min (obtained from the single factor tests), 100 g of Plantaginis Semen sprayed evenly with 2 g of salt (2 g of salt dissolved in 20 mL of water), and fried at 150-180 ℃ for 15 min. Compared with the blank group, both of the raw products group and the salt-processed products group could significantly increase the secretion of urine volume (P<0.01), but the excretion of Na+ in the urine of rats in the salt-processed products group was significantly higher than that in the raw products group (P<0.05). Conclusion:The optimized processing technology is simple and feasible, which can provide reference for standardizing the industrial production of salt-processed products of Plantaginis Semen. At the same time, combined with inherent quality and appearance of the salt-processed products, and verified by pharmacodynamic test, the obtained results are reasonable and reliable, which can be used for quality control of this decoction pieces.
