Clinical Efficacy of Dahuang Zhuyu Decoction for Oral Administration and Enema on Severe Acute Pancreatitis with Syndromes of Blood Stasis, Toxin and Its Effect on Serum Inflammatory Factors
10.13422/j.cnki.syfjx.20191925
- VernacularTitle:大黄逐瘀汤内服与灌肠治疗重症急性胰腺炎瘀毒互结证的临床疗效及对血清炎症因子的影响
- Author:
Xiao-pei HUANG
1
;
Bing-yu QIN
1
;
Rong-qin DAI
1
;
Wen-liang ZHU
1
;
Shi QIU
1
;
Yue WANG
2
;
Huan-zhang SHAO
1
Author Information
1. Henan Provincial People' s Hospital, Zhengzhou 450003, China
2. Children' s Hospital Affiliated to Zhengzhou University, Henan Children' s Hospital, Zhengzhou 450003, China
- Publication Type:Research Article
- Keywords:
Dahuang Zhuyu decoction;
severe acute pancreatitis;
syndromes of blood stasis and toxin;
clinical efficacy;
inflammatory factors;
Dahuang Mudan Tang;
Gexia Zhuyutang
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(2):86-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective::To observe the clinical efficacy of Dahuang Zhuyu decoction for oral administration and enema on severe acute pancreatitis with syndromes of blood stasis and toxin and its effect on serum inflammatory factors. Method::Sixty eight patients with severe acute pancreatitis with syndromes of blood stasis and toxin who were admitted in Henan Provincial People's Hospital from September 2017 to December 2018 were randomly divided into treatment group (34 cases) and control group (34 cases). The control group was treated with western medicine. The treatment group was treated with Dahuang Zhuyu decoction for oral administattion and enema in addition to the therapy of the control group. Both groups were treated for 7 days. Before and after treatment, abdominal pain, bloating, nausea and vomiting were scored separately, serum amylase (AMS), lipase (LPS), interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) were detected, and abdominal pain disappearance time, bloating disappearance time and exhaust recovery time were recorded. Result::After treatment, the abdominal pain score, abdominal distension score, nausea and vomiting score, serum AMS, LPS, IL-6 and TNF-α were lower than those before treatment (P<0.05), and those in treatment group was lower than those in control group (P<0.05). After treatment, IL-10 level in both groups was higher than those before treatment (P<0.05), and that in treatment group was higher than that in control group (P<0.05). The disappearance time of abdominal pain, the disappearance time of abdominal distension and the recovery time of exhaust were shorter in treatment group than in control group (P<0.05). The total effective rate of the treatment group was higher than that of the control group (P<0.05). Conclusion::Dahuang Zhuyu decoction for oral administration and enema for severe acute pancreatitis with syndromes of blood stasis and toxin can alleviate clinical symptoms, reduce amylase and lipase levels, inhibit the expression of pro-inflammatory factors, promote the expression of anti-inflammatory factors, restore intestinal function, and improve clinical efficacy.
