Research Progress on Pharmacological Mechanisms of Scutellarin
10.13422/j.cnki.syfjx.20202240
- VernacularTitle:灯盏花乙素药理作用机制研究进展
- Author:
Wen-xiu GE
1
;
Yun LUO
2
;
Xue-heng XIE
2
;
Gui-bo SUN
2
;
Miao YU
1
;
Xiao-bo SUN
2
Author Information
1. School of Pharmacy ， Engineering Research Center for Medicine ， Harbin University of Commerce， Harbin 150076 ， China
2. Institute of Medicinal Plant Development， Chinese Academy of Medical Sciences， Beijing 100193， China
- Publication Type:Research Article
- Keywords:
scutellarin;
flavonoid;
anti-inflammatory;
antioxidant;
anti-tumor;
molecular mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(22):193-200
- CountryChina
- Language:Chinese
-
Abstract:
Scutellarin is a flavonoid extracted from breviscapus， a traditional Chinese medicine. Pharmacological studies have shown that scutellarin has anti-inflammatory， antioxidant， anti-fibrosis， anti-tumor， improving cardiac and cerebral ischemia. In recent years， with the deepening of research on scutellarin， it was found that it could inhibit the tumor through multi-target and multi-pathway， and the anti-human colorectal cancer was related to the regulation of p53 pathway， Hedgelog pathway and erythropoietin generates liver cancer interactivator B2（EphrinB2）.The anti-esophageal squamous cell carcinoma is related to protein kinaseB1 /protein kinaseB2（ Akt1/Akt2）.Anti-renal carcinoma and melanoma are associated with phosphatase and tension protein homologues（PTEN） and phosphatidylinositol 3-kinase（PI3K）/Akt/mammalian target of rapamycin（mTOR） pathway. Anti-lung cancer is related to Akt/mTOR/4E binding protein1（4EBP1） and signal transduction and transcriptional activator（STAT3 ）signaling pathway. Anti-cervical cancer is related to pyruvate kinase 2（PKM2）.Anti-breast cancer is associated with Hippo/YAP pathway. At the same time， scutellarin was found to prevent diabetic microangiopathy， atherosclerosis and non-alcoholic fatty liver disease by regulating glucose and lipid metabolism， but the mechanism of action was not well studied. A review of the literature found that scutellarin anti-tumor， atherosclerosis， diabetic microangiopathy， non-alcoholic fatty liver disease， osteoarthritis， osteoporosis mechanism of action lack of detailed summary. In this paper， the research progress of pharmacological action and mechanism of scutellarin in recent 5 years is reviewed， and Suggestions on its current research status and future direction are put forward， in order to speed up the discovery of pharmacological mechanism of scutellarin and provide scientific basis for its further development and utilization.
