Research Progress on Antitumor Active Components and Mechanism of Xiao Xianxiongtang
10.13422/j.cnki.syfjx.20201981
- VernacularTitle:小陷胸汤中抗肿瘤作用有效成分及其机制研究进展
- Author:
Rui DING
1
;
Xiang WANG
1
;
Peng ZHOU
1
;
En-yu WANG
1
;
Tong-juan TANG
1
;
Zhong-qiu LI
1
;
Meng-ting ZHAI
1
;
Rui-rui GE
1
;
Jin-ling HUANG
1
Author Information
1. Anhui University of Chinese Medicine， Hefei 230012， China
- Publication Type:Research Article
- Keywords:
Xiao Xianxiongtang;
antitumor;
active ingredients;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(22):186-192
- CountryChina
- Language:Chinese
-
Abstract:
Tumor is one of the diseases that seriously endanger human health， and how to treat tumor effectively is still one of the important problems in the field of medicine. At present， most of the radiotherapies and chemical drugs for cancer have serious side effect despite of an obvious efficacy. With a unique syndrome differentiation treatment system and overall concept， traditional Chinese medicine has become the key research and development object of antitumor drugs due to many advantages， such as multiple channels， multiple levels， multiple links， multiple targets and less toxicity， and could can fully mobilize the immune and epidemic prevention mechanism of the body. A large number of studies have shown that Xiao Xianxiongtang and its effective ingredients have obvious antitumor effect. Many doctors have applied Xiao Xianxiongtang and modified formulas in clinical treatment of tumors， and relevant pharmacological studies have also confirmed the effectiveness of this formula， but with a lack of systematic summary of its effective ingredients and its mechanism of action. Now， with alkaloids， ketones， sterols and phenols in Xiao Xianxiongtang as the starting point， this study mainly focuses on inhibition of tumor cell proliferation， invasion and migration， induction of tumor cell apoptosis and autophagy， inhibition of tumor cell cycle， enhancement of tumor cell sensitivity， inhibition of tumor angiogenesis and regulation of immunosuppressive tumor microenvironment from two ways to sort out composition， function and mechanism of drugs. In this paper， effective components， main targets and mechanism of intervention in the tumor development of Xiao Xianxiongtang were reviewed， in order to provide a new idea for subsequent antitumor research and development of this prescription.
