Feasibility of Hei Xiaoyaosan in Preventing and Treating Alzheimer's Disease Based on Theory of 'Correlation of Liver and Kidney' Based on Ca2+-CaM/CaMKⅡ-CREB Signal Pathway
10.13422/j.cnki.syfjx.20201869
- VernacularTitle:基于“肝肾相关”理论从Ca2+-CaM/CaMKⅡ-CREB信号转导途径探析黑逍遥散防治阿尔茨海默病的可行性
- Author:
Chun-lin MA
1
;
Xiao-xuan FANG
1
;
Bi-yun GAO
1
;
Yue-qin BAI
1
;
Hong-yan WU
2
;
Zhi-xuan ZHANG
3
;
Yong-qiang DUAN
3
Author Information
1. First Clinical Medical College of Shaanxi University of Chinese Medicine， Xianyang 721000， China
2. Shenzhen Hospital Affiliated to Shanghai University of Traditional Chinese Medicine， Shenzhen 518001， China
3. College of Basic Medicine， Gansu University of Chinese Medicine， Lanzhou 730000， China
- Publication Type:Research Article
- Keywords:
correlation of liver and kidney;
Alzheimer's disease;
Ca2+- calcium/calmodulin dependent protein （CaM）/calcium/calmodulin dependent protein kinaseⅡ （CaMKⅡ）-cyclic adenosine phosphate reactive element binding protein （CREB） signal pathway;
Hei Xiaoyaosan
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(23):193-199
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease（AD） is an incipient aging neurodegenerative disease， which increases rapidly along with the development trend of social aging and seriously threatens the health of the people. In the absence of effective preventive measures， it will have an enormous impact on the socio-economic and healthcare system. The study found that abnormal cell signal transduction is a key link in many diseases. Cell signal transduction theory has been widely used to clarify the essence of traditional Chinese medicine visceral image and the mechanism of traditional Chinese medicine. 'Correlation of Liver and Kidney' is one of the core plates of the theory of 'Correlation of Five Organs'， which is suitable for explaining the pathogenesis of complex diseases and the correlation of multiple syndromes， and guiding the prescription of clinical syndrome. Hei Xiaoyaosan， as the first choice compound for the prevention and treatment of AD based on the theory of "Correlation of Liver and Kidney' in our team， can play the effects of prevention and treatment by soothing liver and nourishing blood， strengthening spleen and tonifying kidney， and promoting brain collaterals and dredging viscerab spirit. Based on the theory of 'Correlation of Liver and Kidney'， this paper expounds the pathogenesis of AD from the perspective of traditional Chinese medicine， and puts forward the methods and ideas of the preventing and treating of AD from Ca2+-calcium/calmodulin dependent protein （CaM）/calcium/calmodulin dependent protein kinaseⅡ（CaMKⅡ）-cyclic adenosine phosphate reactive element binding protein （CREB） cell signal transduction pathway by consulting literatures and previous studies.
