Addition and Subtraction Therapy of Buyang Huanwutang Combined with Si Junzitang to Poststroke Fatigue and Antioxidant and Anti-inflammatory with Syndrome of Qi Deficiency and Blood Stasis
10.13422/j.cnki.syfjx.20200732
- VernacularTitle:补阳还五汤合四君子汤加减治疗中风后疲劳气虚血瘀证和抗氧化及抗炎的作用
- Author:
Yan-zhen WANG
1
;
Wei-feng WANG
2
;
Yu-lan AN
2
;
Hui-fang ZHAO
3
;
PENG ZHANG
3
;
Zai-wei ZHANG
4
;
Jun-qin ZHANG
1
Author Information
1. Xinzhou Vocational and Technical College，Xinzhou 034007，China
2. Third Hospital of Shanxi Medical College，Taiyuan 034006，China
3. Shanxi Xinzhou Traditional Chinese Medicine Hospital，Xinzhou 034007，China
4. Affiliated Hospital of Medical College of Datong University，Yuanping 034100，China
- Publication Type:Research Article
- Keywords:
poststroke fatigue;
syndrome of Qi deficiency and blood stasis;
Buyang Huanwutang;
Si Junzitang;
acupuncture;
antioxidant;
anti-inflammatory
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(23):131-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate effect of addition and subtraction therapy of Buyang Huanwutang combined with Si Junzitang and acupuncture to poststroke fatigue （PSF） and syndrome of Qi deficiency and blood stasis， at the same time we studied the antioxidant and anti-inflammatory effects. Method:One hundred and forty-four patients were randomly divided into control group and observation group （1∶1） by random number table. 66 patients in control group completed the therapy （4 patients were falling off or missing visit， 2 patients were eliminate）， 67 patients in observation group completed the therapy （2 patients were falling off or missing visit， 3 patients were eliminate）. In control group， patinets got acupuncture， 1 time/day， 6 times/week， they also got Geqi Tongmai grain， 10 g/time， 3 times/day. Patients in observation group got acupuncture （the same as which in control group）， and addition and subtraction therapy of Buyang Huanwutang combined with Si Junzitang， 1 dose/day， and courses of treatment in two groups were 4 weeks. Before and after treatment， fatigue severity scale （FSS）， NIH stroke scale （NIHSS）， syndrome of Qi deficiency and blood stasis， stroke specific quality of life scale （SS-QOL）， and scores of ability of daily life （ADL） were recorded. And levels of superoxide dismutase （SOD）， malondialdehyde （MDA）， glutathione peroxidase （GSH-Px）， homocysteine （Hcy）， interleukin-1β （IL-1β）， IL-6， tumor necrosis factor-α （TNF-α） and C-reactive protein （CRP） were detected. And the safety evaluated. Result:Disease effect in observation group was better than which in control group （Z=2.118， P<0.05）. And effect after using traditional Chinese medicine （TCM） was also better than that in control group （Z=2.046， P<0.05）. Scores of FSS， syndrome of Qi deficiency and blood stasis， NIHSS， and levels of IL-1β， IL-6， Hcy， CRP， TNF-α and MDA in observation group were all lower than those in control group （P<0.01）， and scores of SS-QOL， ADL， and levels of GSH-Px and SOD were all higher than those in control group （P<0.01）. Then there was no related safety issues caused by drug. Conclusion:Addition and subtraction therapy of Buyang Huanwutang combined with Si Junzitang and acupuncture had effect of anti-oxidation and anti-inflammatory， and can significantly reduce fatigue and degree of neurological impairment and can improve patients' quality of life and daily life ability. The clinical effect is significant and safe， which is worthy of further research and application.
