Research Progress of Banxia Houpu Tang in Treatment of Depression
10.13422/j.cnki.syfjx.20202339
- VernacularTitle:半夏厚朴汤治疗抑郁症研究进展
- Author:
Meng-di MAO
1
;
Li-zhi SHANG
1
;
Er-ping XU
1
Author Information
1. Academy of Chinese Medical Sciences，School of Basic Medical Science，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Research Article
- Keywords:
Banxia Houpu Tang;
depression;
clinicalapplication;
experimentalstudy;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(23):37-43
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a common emotional disease，causing a heavy burden of disease on patients' families and society.Its pathogenesis is not yet fully understood，andmay be related to inflammation，neurotransmitters，neurotrophicfactors，hippocampal neuronal synaptic plasticity，oxidative stress，etc.Clinical application of Western medicine to treat depression has serious side effects，poor patient compliance，the effective rate is not high，rebound after withdrawal，etc.Traditional Chinese medicine treatment of depression has the characteristics of low side effects and high patient compliance. Depression belongs to the category of depression syndromein traditional Chinese medicine.Traditional Chinese medicine believes that the main symptoms of depression include depressed liver Qi，stagnated Qi transforming into fire，deficiency in heart and spleen，deficiency in heart and lung，stagnation of phlegm and Qi，deficiency of liver and kidney，etc. Banxia Houpu Tang is a classic recipe contained in"Synopsis of the Golden Chamber" by Zhang Zhongjing in the Han Dynasty， it has the effect of treating depression syndrome of stagnation of phlegm and Qi.By searching the literatures of Banxia Houpu Tang in the treatment of depression in Chinese knowledge network database （CNKI），Chinese biomedical literature database （CBM）， Wanfang Data， Pubmed， Embase， Web of Science and other databases，we found that both clinical application and experimental research suggest that Banxia Houpu Tang has a significant antidepressant effect. Clinical studies have shown that Banxia Houpu Tang can improve the scores of anxiety scales and depression scales of patients with depression. The antidepressant effect is significant， and the advantages are prominent. Experimental research shows that the antidepressant effect of Banxia Houpu Tang and its effective components may be related to the factors such as intervention of inflammatory response， influence of neurotransmitters， regulation of neurotrophic factors， improvement of synaptic plasticity of hippocampal neurons and reduce oxidative stress，etc. Therefore，this paper reviews several types of depression in the clinical treatment of Banxia Houpu Tang and the related experimental studies of Banxia Houpu Tang.
