Meta-analysis of Therapeutic Efficacy of Yixinshu Preparation Combined with Conventional Therapy in the Trea- tment of Angina Pectoris of Coronary Heart Disease
- VernacularTitle:益心舒制剂联合常规治疗方案治疗冠心病心绞痛效果的Meta分析
- Author:
Yingjie HUANG
1
;
Lei HUANG
1
;
Yuxuan TAO
1
;
Haiyi LI
1
;
Yueyao ZHANG
1
;
Junmao WEN
1
;
Wei WU
2
Author Information
1. The First Clinical Medicine School，Guangzhou University of TCM，Guangzhou 510405，China
2. Dept. of Cardiovascular Medicine，the First Affiliated Hospital of Guangzhou University of TCM，Guangzhou 510405，China
- Publication Type:Journal Article
- Keywords:
Yixinshu;
Drug combination;
Coronary heart disease;
Angina pectoris;
Therapeutic efficacy;
Meta-analysis
- From:
China Pharmacy
2021;32(3):339-345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To systematically evaluate therape utic efficacy of Yixinshu preparation combined with conventional treatment plan for angina pectoris of coronary heart disease （CHD）vs. conventional treatment plan ，and to provide evidence-based reference for clinical drug use. METHODS ：Retrieved from Cochrane library ，PubMed，Embase，CBM，CNKI，Wanfang database and VIP ，randomized controlled trials （RCTs）about Yixinshu preparation combined with conventional treatment plan （trial group ） versus conventional treatment plan （control group ）for angina pectoris of coronary heart disease were collected during Jan. 1st in 2012 to Oct. 1st in 2020. After extracting the data ，the quality of included studies were evaluated with Cochrane System Evaluator Handbook 5.3；Meta-analysis was performed by using Stata 15.0 software. RESULTS ：A total of 23 RCTs involving 2 853 subjects were included. The results of Meta-analysis showed that the efficacy of angina pectoris [RR ＝0.92，95％CI（0.87，0.97），P＜0.05]， the times of angina pectoris attack [SMD ＝－0.98，95％CI（－1.09，－0.87），P＜0.05]，the duration of angina pectoris [SMD ＝ －0.77，95％CI（－0.88，－0.67），P＜0.05]，ECG curative effect [RR ＝0.91，95％CI（0.84，0.98），P＜0.05] and the improve rate of TCM syndromes [RR ＝0.89，95％CI（0.85，0.94），P＜0.05] in trial group were all better than control group ，with statistical significance. CONCLUSIONS ：Yixinshu preparation combined with conventional treatment plan is better than conventional treatment plan in terms of improving therapeutic efficacy of angina pectoris and ECG ，TCM syndrome improvement rate ，as well as reducing the frequency of angina pectoris attack ，angina pectoris attack duration.
