Case Report and Literature Analysis of Antidepressants-induced Thrombocytopenia
- VernacularTitle:抗抑郁药致血小板减少症的文献病例分析
- Author:
Shuang BAO
1
,
2
;
Hongyan ZHUANG
1
,
2
;
Shanshan LIU
1
,
2
;
Mengxi NIU
1
,
2
;
Yannan ZANG
1
,
2
;
Xiaoqian LAN
1
,
2
;
Fei JIA
1
,
2
;
Wei GUO
1
Author Information
1. Dept. of Pharmaceutical Affair，Beijing Anding Hospital Affiliated to Capital Medical University/National Medical Research Center for Mental Disorders/Beijing Key Laboratory for Diagnosis and Treatment of Mental Disorders，Beijing 100088，China
2. Advanced Innovation Center for Human Brain Protection，Capital Medical University，Beijing 100069，China
- Publication Type:Journal Article
- Keywords:
Antidepressants;
Thrombocytopenia;
Platelet
- From:
China Pharmacy
2021;32(3):334-338
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To investigate the clini cal features of thrombocytopenia induced by antidepressants ，and to provide reference for the rational use of clinical drugs. METHODS ：Retrieved from CNKI ，Wanfang database ，VIP，PubMed and Web of Science，during Jan. 1st in 1985 to Aug. 31st in 2020，case reports about antidepressants-induced thrombocytopenia was collected and analyzed descriptively in terms of demographic characteristics ，medication，clinical manifestations ，treatment and outcome. RESULTS：A total of 17 literatures were retrieved ，and 19 patients were included ，involving 10 male and 9 female，aged from 5 to 95 years old ，with an average of （48±24）years old. Nine kinds of drugs were involved ，including 4 cases of escitalopram ，3 cases of citalopram ，3 cases of fluoxetine ，3 cases of mirtazapine ，2 cases of amitriptyline ，1 case of sertraline ，1 case of paroxetine，1 case of mianserin and 1 case of imipramine. There were 9 cases of single drug and 10 cases of drug combination. All 19 patients suffered from thrombocytopenia at 3 d-10 years after medication ，14 of them had hemorrhage tendency. Main clinical manifestations included mucocutaneous hemorrhage ，gingival bleeding ，black stool ，hematochezia，vaginal bleeding ，ocular hemorrhage，alveolar hemorrhage. No bleeding was found in 5 cases. After drug withdrawal/changing drugs and other symptomatic treatment， platelet count of 19 patients recovered to normal ， and bleeding symptoms disappeared. CONCLUSIONS ： Thrombocytopenia caused by antidepressants has no obvious clinical features and is not easy to be found ，but it may lead to severe； bleeding symptoms if it is not found in time. The changes of platelet count should be closely monitored in clinical application of such drugs to ensure the safety of drug use.
