Interpretation of Theory of Weiluo Tongxin and Its Potential Molecular Mechanism Based on Zhishi Xiebai Guizhitang
10.13422/j.cnki.syfjx.20201153
- VernacularTitle:基于枳实薤白桂枝汤阐释“胃络通心”理论及其潜在分子作用机制
- Author:
Feng-rong ZHANG
1
;
Xiao-xuan FAN
2
;
Zhi-yong LI
1
;
Shi-huan TANG
1
Author Information
1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences， Beijing 100700，China
2. College of Traditional Chinese Medicine （TCM）， Shandong University of TCM，Ji′nan 250300， China
- Publication Type:Research Article
- Keywords:
Weiluo Tongxin;
Zhishi Xiebai Guizhitang;
molecular mechanism;
integrative pharmacology;
inflammation;
cardiovascular disease;
traditional Chinese medicine theory
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(24):30-37
- CountryChina
- Language:Chinese
-
Abstract:
The scientific interpretation of the connotation of traditional Chinese medicine （TCM） theory is an important part of the development of TCM. Combined ancient classic theories with modern science and technology is a new path for the innovative development of TCM theory. Based on this， taking Zhishi Xiebai Guizhitang as an example， the molecular mining technology of integrative pharmacology-based research platform of TCM V2.0 （TCMIP V2.0） was used to analyze the mechanism of Zhishi Xiebai Guizhitang in preventing and treating gastropathic stomachache. A total of 220 chemical components in Zhishi Xiebai Guizhitang were obtained， and 674 targets were involved， of which 12 core targets directly affected angina pectoris and gastroesophageal reflux disease， including insulin （INS）， glyceraldehyde-3-phosphate dehydrogenase （GAPDH）， RAC-α serine/threonine-protein kinase 1 （AKT1）， tumour protein p53 （TP53）， albumin （Alb）， mitogen-activated protein kinase 3 （MAPK3）， interleukin-6 （IL-6）， etc. And tumor necrosis factor （TNF） signaling pathway， phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt） signaling pathway， IL-17 signaling pathway， hypoxia-inducible factor-1 （HIF-1） signaling pathway and other 121 pathways involved in these related diseases. All of these are the biological basis of Weiluo Tongxin theory. Combing the classical theories of TCM combined with the exploring the molecular mechanism of representative prescriptions can provide a demonstration and reference for the scientific connotation research of TCM theory.
