Natural products in the prevention and treatment of melanoma

VernacularTitle:天然产物在黑色素瘤防治中的研究进展
Author: Yue GAO ; Xiao-ping WANG ; Min LI ; Ren-jie DOU ; Lei QIANG
Publication Type:Research Article
Keywords: melanoma; natural product; antitumor; prevention; treatment
From: Acta Pharmaceutica Sinica 2021;56(1):92-101
CountryChina
Language:Chinese
Abstract: The incidence of malignant melanoma, a highly fatal skin tumor, is on the rise worldwide. Melanomas are highly aggressive and have strong metastatic capability that leads to lethality. Recurrence occurs in patients with distant metastases, even with the latest treatments, and median survival is only a few months. At present, the prevention and treatment of melanoma includes surgical resection, chemotherapy, immunotherapy and targeted therapy. However, these strategies can lead to drug resistance and adverse effects. In recent years, an increasing number of studies have found that natural products have effective anti-melanoma activities, including inhibition of tumor growth, induction of cell apoptosis, inhibition of angiogenesis and metastasis and toxicity to tumor stem cells. In addition, several studies have reported that the combination of natural products and traditional anti-melanoma drugs can enhance the therapeutic efficacy. In this review we summarize the prevention and treatment of melanoma with natural products.