Chemical constituents of triterpenoid saponins from <italic>Glycyrrhiza glabra</italic>

Yun-feng ZHENG; Jie SUN; Wei-ping DUAN; Yang LI; Li-hong CHEN; Tu-lin LU; Cun-yu LI; Gou-ping PENG

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Chemical constituents of triterpenoid saponins from Glycyrrhiza glabra

VernacularTitle:光果甘草三萜皂苷类化学成分研究
Author: Yun-feng ZHENG ^{1
,

2} ; Jie SUN ¹ ; Wei-ping DUAN ¹ ; Yang LI ¹ ; Li-hong CHEN ¹ ; Tu-lin LU ¹ ; Cun-yu LI ^{1
,

2} ; Gou-ping PENG ^{1
,

2}
Author Information

1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China
Publication Type:Research Article
Keywords: italic>Glycyrrhiza glabra L.; chemical composition; triterpenoid saponin
From: Acta Pharmaceutica Sinica 2021;56(1):289-295
CountryChina
Language:Chinese
Abstract: Ten triterpenoid saponins were isolated and purified from the water extract of Glycyrrhiza glabra by polyamide resin combined with macroporous resin column chromatography, ODS medium pressure column chromatography and semi-preparative RP-HPLC. Their structures were elucidated by physicochemical properties, NMR and MS spectra, and determined as 3β-O-[β-D-glucuronpyranosyl-(1→2)-β-D-glucuronpyranosyl]-30β-O-β-D-glucuronpyranosyl-oleanane-11-oxo-12(13)-ene (1), 3β-O-[β-D-glucuronpyranosyl-(1→2)-β-D-glucuronpyranosyl]-30β-O-α-L-rhamnopyranosyl-oleanane-11-oxo-12(13)-en-22β,30-diol (2), uralsaponin C (3), licorice-saponin A3 (4), licorice-saponin P2 (5), 22β-acetoxyl-glycyrrhizin (6), macedonoside A (7), 29-hydroxyl-glycyrrhizin (8), licorice-saponin G2 (9), glycyrrhizin (10). Compounds 1 and 2 are two new compounds and named as licorice-saponin R3 and licorice-saponin S3.