A new polyacetylene from the stems and leaves of <italic>Chrysanthemum morifolium</italic> Ramat

Jing-ya SHI; Meng LI; Meng-nan ZENG; Jing-ke ZHANG; Juan-juan LIU; Deng-hui ZHU; Xiao-ke ZHENG; Wei-sheng FENG

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A new polyacetylene from the stems and leaves of Chrysanthemum morifolium Ramat

VernacularTitle:怀菊花茎叶中一个新聚炔类化合物
Author: Jing-ya SHI ^{1
,

2} ; Meng LI ^{1
,

2} ; Meng-nan ZENG ^{1
,

2} ; Jing-ke ZHANG ^{1
,

2} ; Juan-juan LIU ^{1
,

2} ; Deng-hui ZHU ^{1
,

2} ; Xiao-ke ZHENG ^{1
,

2} ; Wei-sheng FENG ^{1
,

2}
Author Information

1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
Publication Type:Research Article
Keywords: italic>Chrysanthemum morifolium; stem and leave; chemical constituent; polyacetylenes; cytotoxicity
From: Acta Pharmaceutica Sinica 2021;56(1):283-288
CountryChina
Language:Chinese
Abstract: Eight polyacetylenes were isolated from the extract of the stems and leaves of Chrysanthemum morifolium by various chromatographic methods. Their structures were determined as 2E,4E,12Z-tetradecatriene-1-pyrrolidine-1-oxo-8,10-diynoic (1), tetradeca-2E,4E,12E-trien-8,10-diynoic acid pyrrolidide (2), tetradeca-2E,4E-dien-8,10-diynoic acid pyrrolidide (3), tetradeca-2E,4E,10Z-trien-8-ynoic acid pyrrolidide (4), 2E,4E,12E-tetradecatriene-8,10-diynoic acid isobutylamide (5), 2E,4E-undecyldiene-8,10-diynoic acid isobutylamide (6), 2E,4E,10E-N-isobutyl-2,4,10-tetradecatrien-8-ynoic acid amide (7), and undeca-2E,4E-diene-8,10-diynoic acid phenylethylamide (8) by spectroscopic methods, including UV, IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR spectra. Among them, compound 1 is a new polyacetylene, and compounds 2-8 were isolated from this plant for the first time. Compounds 5-8 inhibited the proliferation of A549 cell significantly at certain concentration, showing potent antitumor activity.