Strategy to delay the progression of chronic kidney disease by targeting gut microbiota and uremic toxins metabolism pathway
10.16438/j.0513-4870.2020-1246
- VernacularTitle:靶向肠道菌群调控肠源尿毒素代谢通路干预慢性肾病进展的治疗策略分析
- Author:
Yin PENG
;
Xue-jun XU
;
Jian-ping LI
;
Cheng-xi LI
;
Jia-ting YIN
;
Jin-ao DUAN
;
Jian-ming GUO
- Publication Type:Research Article
- Keywords:
chronic kidney disease;
gut microbiota;
gut-derived uremic toxin;
indoxyl-sulfate;
italic>p-cresol sulfate
- From:
Acta Pharmaceutica Sinica
2021;56(1):37-49
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease (CKD) is a serious chronic disease with high incidence, poor prognosis, and a variety of complications. Indoxyl-sulfate (IS) and p-cresol sulfate (PCS) are two typical gut-derived uremic toxins, which are produced by the co-metabolism of intestinal microbes and the host. With the progression of CKD, gut-derived uremic toxins such as IS and PCS accumulate in patients with CKD and thereafter accelerate the progression of CKD. Gut microbiota is closely related with CKD, and targeting gut microbiota to regulate gut-derived uremic toxins synthesis and metabolic pathways may be a promising strategy to delay the progression of CKD. In this paper, the relationship between gut microbiota, gut-derived uremic toxins, and CKD was analyzed, and the strategy to delay the progression of CKD by targeting gut microbiota and uremic toxins metabolism pathway was proposed.
