Prospects for histone deacetylase inhibitors as antidepressants

VernacularTitle:组蛋白去乙酰化酶抑制剂的抗抑郁前景
Author: Kai-yun YAO ; Hong-wan DING ; Lin-yu CAO ; Yin-ge GAO ; Jian-jun ZHANG ; Gui-bin WANG
Publication Type:Research Article
Keywords: histone deacetylase inhibitor; epression; epigenomics; acetylation
From: Acta Pharmaceutica Sinica 2021;56(1):29-36
CountryChina
Language:Chinese
Abstract: Depression is a serious mental illness with a high incidence. At present, we do not fully understand the specific pathological mechanisms of depression, and the efficacy of drug treatments is very limited. Recent studies have shown that epigenetic changes that occur in specific brain regions may be a key mechanism by which environmental factors to interact with individuals to influence the risk of depression. Therefore, drugs that target epigenetic regulation may become a new direction for the development of antidepressants. Histone deacetylase inhibitors (HDACi) are a class of compounds that inhibit histone deacetylase activity, which has been reported to be associated with depression; this article addresses the use of HDACi in preclinical studies, and their potential therapeutic role and limitations of use in depression.