Analysis of technical difficulties and new strategies of oral liquid pharmaceutical preparation for children
10.16438/j.0513-4870.2020-1196
- VernacularTitle:儿童口服液体药物制剂的技术难点及研发策略分析
- Author:
Xin CHEN
1
;
An LU
1
;
Xiang-yu WANG
1
;
Xiao-ling WANG
2
;
Ai-ping ZHENG
3
;
Jian-cheng WANG
1
Author Information
1. School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
2. Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
3. Institute of Pharmacology and Toxicology of the Academy of Military Medical Sciences, Beijing 100850, China
- Publication Type:Research Article
- Keywords:
oral drug administration;
pediatrics;
liquid pharmaceutical preparation;
emulsion;
ion exchange resin
- From:
Acta Pharmaceutica Sinica
2021;56(1):130-137
- CountryChina
- Language:Chinese
-
Abstract:
With the implementation of the two-child policy and the growing demand for child health, pediatric medication has been arousing widespread social concern. To develop the drugs suitable for children, including new compounds, new specifications and new dosage forms, is urgently required for pharmaceutical researchers. In this review, several technical bottlenecks for pediatric oral liquid preparations, as well as the novel strategies involved in drug nanocrystals, self-microemulsion, ion exchange resin and Pickering emulsion were discussed, which may be benefit to play a theoretical guiding role in the research and development of children's oral liquid formulation.
