The mechanism of androgen independent signaling pathway in castration-resistant prostate cancer and the research progress on related drugs
10.16438/j.0513-4870.2020-1162
- VernacularTitle:去势抵抗前列腺癌中的非激素信号通路作用机制及其相关药物研究进展
- Author:
Meng-xia XUE
;
Yue GU
;
Jian-guo SUN
;
Guang-ji WANG
;
Ying PENG
- Publication Type:Research Article
- Keywords:
prostate cancer;
castration resistance;
androgen independent;
signal pathway;
rug development
- From:
Acta Pharmaceutica Sinica
2021;56(1):21-28
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is one of the common malignant tumors of male urogenital system, and the incidence of prostate cancer in China has increased significantly in the past decade. At present, endocrine therapy based on androgen blockade is the main method of clinical treatment except radical surgery and radiotherapy/chemotherapy for prostate cancer. However, the clinical benefit can only be obtained in the early stage of treatment, and nearly 90% of patients will develop to the castration resistance, and among them, nearly 90% of patients will have bone metastasis. The quality of life decreases sharply with the progression of disease for patients. In addition to the androgen signal pathway, studies have shown that many other oncogenic signal pathways have involved in the development of castration resistance, including classic cancer signaling pathways, immune and inflammatory signaling pathways, etc. Understanding the mechanism of androgen independent signal pathway in the formation of castration resistance will help to understand the off-target effect of androgen blocking therapy and introduce new treatment targets or strategies to get rid of the "no drug available" dilemma for clinical treatment of castration resistance.
