Application of natural deep eutectic solvents in pharmaceutics
10.16438/j.0513-4870.2020-1148
- VernacularTitle:天然低共熔溶剂在药剂学中的应用
- Author:
Jing-jing XUAN
1
,
2
;
Xi-ying WU
3
;
Jian-ping QI
4
;
Jie ZHUANG
5
,
6
Author Information
1. Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2. School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
3. Shanghai Dermatology Hospital, Shanghai 200443, China
4. School of Pharmacy, Fudan University, Shanghai 201203, China
5. School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
6. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
natural deep eutectic solvent;
ionic liquid;
increasing solubility;
enhancing permeation;
rug eutectic
- From:
Acta Pharmaceutica Sinica
2021;56(1):146-157
- CountryChina
- Language:Chinese
-
Abstract:
Natural deep eutectic solvent (NDES) is a kind of deep eutectic solvents (DESs) which is composed of natural substances with good biocompatibility. Those substances can function as hydrogen bond donor and acceptor, such as choline, amino acids, sugars, etc. NDES have been widely used in many fields due to their advantages of low cost, easy preparation and environmental friendliness. It is especially suitable for the pharmaceutical industry because of its good biocompatibility and safety for use. In this paper, we firstly review the molecular simulation methods for current design of DESs from the formation principle. And then, the materials and preparation of NDES are reviewed and the physicochemical properties are further described. Finally, we review the current application of NDES in pharmaceutics including increasing drug solubility, promoting drug permeability and enhancing oral drug absorption, and meanwhile their future applications in pharmaceutics were also prospected.
