Research and application of nanometer black phosphorus in phototherapy and drug carrier

VernacularTitle:纳米黑磷在光疗和药物载体方面的研究与应用
Author: Xin-meng LI ; Jia-yue LI ; Xin ZHANG ; Sheng-ji TIAN ; Shi-chao XIAO ; Meng-yu YAO ; Dan-qing LIU ; Ying GUO
Publication Type:Research Article
Keywords: black phosphorus; phototherapy; rug carrier; photodynamic; photothermal
From: Acta Pharmaceutica Sinica 2021;56(1):178-189
CountryChina
Language:Chinese
Abstract: The emerging nano-black phosphorus materials have created a new platform for biomedical research. Nano-black phosphorus has the following advantages: black phosphorus can produce singlet oxygen under near-infrared light irradiation, so it can be used as a photosensitizer for photodynamic therapy;black phosphorus has extensive light absorption in the long wavelength region, and this near-infrared photothermal property can be used in photothermal therapy. The high specific surface area and unique fold structure of the black phosphorus nanosheet make it have very high drug loading.This paper mainly reviews the applications of black phosphorus in biological imaging, photothermal therapy, photodynamic therapy, and as a drug carrier in recent years. Based on the photoelectric properties of black phosphorus nanomaterials combined with intelligent drug delivery platform, the synergistic effects of light/heat/chemistry, light/chemistry/gene, and light/chemistry/immunity can be produced, which has a broad application prospect.